2025, Vol. 5, Issue 2, Part C
Physiological effect of thiamin on cardiovascular system in adult rate treated with erythromycin
Author(s): Mohammed Hayder Asker
Abstract: Background: Erythromycin is a common solution of macrolide antibiotics which has cardiovascular side effects, such as oxidative stress and myocardial damage. Thiamin (vitamin B1), which is an important coenzyme in energy metabolism, has anti-inflammatory and antioxidant properties. This research paper set out to examine the protective action of thiamin on cardiovascular toxicity induced by erythromycin in adult albino rats. Methods: Four groups (n= 10 each) of male Swiss albino rats were assigned to control (normal saline), thiamin (400 µg/kg), erythromycin (400 mg/kg), and thiamin + erythromycin (2.4 µg/kg + 400 mg/kg) groups. Treatments were administered in two months orally. The level of malondialdehyde (MDA), glutathione (GSH), creatine kinase (CK), aspartate aminotransferase (AST), lipid profile, C-reactive protein (CRP) and interleukin-6 (IL-6 were measured by biochemical assay. The myocardium and aorta were examined histopathologically by use of the hematoxylin and eosin stains. Results: MDA, CK, AST, CRP, IL-6, and induced dyslipidemia, and GSH was reduced (p<0.001 vs. control) on erythromycin treatment. The biochemical parameters were kept close to normal levels by thiamin supplementation and the changes caused by erythromycin were greatly decreased. It was found that histological sections of erythromycin-treated rats contained coagulative necrosis, fatty infiltration, inflammation and hemorrhage, and that thiamin co-treatment reinstated myocardial architecture with minor pathology. Conclusion: The study indicates that supplementation of Thiamin has a protective effect on cardiovascular toxicity caused with erythromycin and improves antioxidant defenses, biochemical markers, and histological integrity. These results point to the use of thiamin as a possible complementary treatment to minimize cardiac adverse event of prolonged erythromycin consumption.
DOI: 10.22271/letters.2025.v5.i2c.155
Pages: 210-215 | Views: 67 | Downloads: 35
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How to cite this article:
Mohammed Hayder Asker. Physiological effect of thiamin on cardiovascular system in adult rate treated with erythromycin. Zool Entomol Lett 2025;5(2):210-215. DOI: 10.22271/letters.2025.v5.i2c.155
