2025, Vol. 5, Issue 2, Part B
Targeting bacterial quorum sensing pathways nanoparticle-based inhibitors
Author(s): Ali Hilal Abdul-Ameer Al-Emran, MA Khuadher, Hussein S Obaid and Hussein Turki Hilal
Abstract:
Bacterial quorum sensing (QS) is a cell density-regulated process that controls important pathogenic processes, e.g.; production of virulence factors, biofilm formation, antibiotic resistance. Interfering with QS in this manner via quorum sensing inhibitors (QSIs) is a potentially effective form of anti-virulence not subject to the selective pressures of bactericidal drugs. Conventional QSIs however have weak solubility, are unstable, have poor bioavalabilty and their activity spectrum is limited. New nanotechnology Nanoparticle-based QSIs or NP-QSIs are the new generation of tools, having the potential to overcome these limitations, through recently advanced nanotechnology.
In this article, the authors give a detailed review of the nanoparticle-mediated quorum sensing inhibition. It explains the characteristics of the nanoparticles used, which are metallic, polymeric and lipid-based nanoparticles and also hybrid systems and how they work in ruining the signals, antagonizing the receptors, regulating the genes, and about the disruption of the biofilms. The case studies conducted recently attesting the effectiveness of NP-QSIs both in vitro and in vivo models, as well as the obstacles of the targeting specificity, delivery, cytotoxicity, and environmental safety are tested. Other potential avenues will be multifunctional smart nanocarriers, combination with diagnostic platforms, and alignment of the Ag combat with antimicrobial stewardship. Targeting of quorum sensing by nanoparticles is a potentially successful anti-infective approach that holds the potential to revolutionize the treatment of multidrug-resistant and chronic disease using non-lethal quorum sensing disruption.DOI: 10.22271/letters.2025.v5.i2b.143
Pages: 117-126 | Views: 101 | Downloads: 44
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How to cite this article:
Ali Hilal Abdul-Ameer Al-Emran, MA Khuadher, Hussein S Obaid, Hussein Turki Hilal. Targeting bacterial quorum sensing pathways nanoparticle-based inhibitors. Zool Entomol Lett 2025;5(2):117-126. DOI: 10.22271/letters.2025.v5.i2b.143
