2025, Vol. 5, Issue 1, Part B
Modulation of inflammatory cytokines by curcumin: A key factor in its protective effects against cisplatin-induced kidney toxicity in rats
Author(s): Fahem MD AL-Shebly
Abstract: Background: Cisplatin is a widely used chemotherapeutic agent known for its potent anti-cancer activity; however, its clinical use is often limited by dose-dependent nephrotoxicity mediated through oxidative stress and inflammation. Curcumin, a natural polyphenolic compound, has shown promising anti-inflammatory and antioxidant properties in various disease models.
Objective: This study aimed to investigate the protective
effects of curcumin against cisplatin-induced kidney toxicity in rats by
evaluating its modulatory effects on key inflammatory cytokines: TNF-α, IL-6,
and IL-10.
Methods: Forty adult male Wistar rats were randomly assigned
to four groups: Control, Cisplatin (7.5 mg/kg, i.p., single dose on day 20),
Cisplatin + Curcumin (300 mg/kg, I.P. daily for 25 days), and Curcumin-only
(300 mg/kg, i.p. daily for 25 days). At the end of the experiment, blood
samples were analyzed for TNF-α, IL-6, and IL-10 levels using ELISA.
Results: Cisplatin administration significantly increased
TNF-α and IL-6 levels while markedly decreasing IL-10 compared to the control
group (p<0.0001). Curcumin co-treatment significantly reduced TNF-α
and IL-6 levels and restored IL-10 expression toward normal values (p<0.0001),
indicating a strong anti-inflammatory and immunomodulatory effect.
Conclusion: Curcumin significantly attenuates cisplatin-induced
renal inflammation by modulating the expression of pro- and anti-inflammatory
cytokines. These findings support the potential of curcumin as a complementary
therapeutic agent to reduce cisplatin-associated nephrotoxicity.
DOI: 10.22271/letters.2025.v5.i1b.124
Pages: 101-105 | Views: 116 | Downloads: 52
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How to cite this article:
Fahem MD AL-Shebly. Modulation of inflammatory cytokines by curcumin: A key factor in its protective effects against cisplatin-induced kidney toxicity in rats. Zool Entomol Lett 2025;5(1):101-105. DOI: 10.22271/letters.2025.v5.i1b.124
