2024, Vol. 4, Issue 2, Part A
Impact of mancozeb on sperm quality and hormonal profiles in male rats at different periods
Author(s): Mohammed Fadhil K Alrubaie and Sura Safi Khafaji
Abstract: The Mancozeb are reported to cause repro-toxicity. The present study was directed to investigate the time of Mancozeb on testicular toxicity in male rats. Twenty four adult male rats were grouped randomly into two groups (n=12) as follows: the control group received normal saline, treatment group (T) was administration 313.5 mg/kg of Mancozeb for three periods 0, 15 and 30 days. In comparison with control male rats, the Mancozeb-treated rats revealed a significant decrease in sperm count, sperm motility, and sperm viability, and a significant increase in sperm abnormality after 30 days of treatments. The male rats treated with Mancozeb displayed a significant decrease in serum LH, FSH, and testosterone concentrations compared with the control group after 30 days of treatment. In comparison among the treatment periods (0, 15, and 30 days), the serum concentrations of FSH, testosterone, and LH gradually decreased in male rats treated with Mancozeb during these periods, The administration of Mancozeb for 15 days showed a normal appearance of the testicular tissue section of rats received Mancozeb for 30 days showed germinal epithelium damage and testicular atrophy accompanied by losing interstitial cells, reducing quantities and diameters of spermatocytes. Conclusion: Mancozeb could potentially cause serious impairments in the reproductive system, mainly by mechanisms of oxidative stress and disruption of the endocrine system. The risk of damage is higher with increased dosage and length of exposure; this points to a need for caution in its use and further investigation into its effects on human and animal reproductive health.
DOI: 10.22271/letters.2024.v4.i2a.106
Pages: 54-59 | Views: 262 | Downloads: 183
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How to cite this article:
Mohammed Fadhil K Alrubaie, Sura Safi Khafaji. Impact of mancozeb on sperm quality and hormonal profiles in male rats at different periods. Zool Entomol Lett 2024;4(2):54-59. DOI: 10.22271/letters.2024.v4.i2a.106
